Postdoctoral Scholars at the Gluck Equine Research Center

Amanda Adams, PhD

Gluck Equine Research Center
Department of Veterinary Science
University of Kentucky
Lexington, KY 40546-0099

amanda.adams@uky.edu
Tel: 859-257-4757 ext. 81202
Fax: 859-257-8542

Amanda Adams obtained her Bachelors of Science with a major in Biology and minors in Chemistry and Equestrian Business Management in 2003 from Stephens College, Columbia, Missouri.  During her undergraduate career she worked in Equine Research Development for both Boehringer Ingelheim Vetmedica, Saint Joseph, Missouri and Intervet, Inc., DeSoto, Kansas.  Subsequently she conducted her Ph.D. research under the direction of Dr. David W. Horohov at the Gluck Equine Research Center, University of Kentucky, studying immunosenescent and inflamm-aging changes in equine immune function, and received her degree in 2008.  Currently, she is a post-doctoral scholar in Dr. David Horohov’s laboratory.  Her current research is focused on determining the effects of dietary components including tocopherols, omega fatty acids and plant polyphenols on age-associated changes of immune and inflammatory responses in old horses and to investigate mechanisms responsible for inflamm-aging that may involve T cell lipid raft signaling.  In addition, she is working on other research projects that include characterization of the foal’s immune response, in particular, the cell-mediated responses to early influenza vaccination and to further understand the process of maternal interference. 

Publications:

Adams, AA, Breathnach, CC, Sturgill, T, Chambers, T and Horohov, DW.  Comparison of humoral and cell-mediated immune responses of young and old horses following influenza recombinant canaraypox virus vaccination and challenge.  Manuscript submitted to Vaccine, Jan 2009.

Adams, AA, Katepalli, M, Kohler, K, Reedy, S, Stilz, JP, Vick, MM, Fitzgerald, BP and Horohov, DW.  Effect of body condition, body weight and adiposity on inflammatory cytokine responses in old horses.  Manuscript accepted October 31, 2008 [Epub ahead of print] to Veterinary Immunology and Immunopathology.

Adams AA, Breathnach CC, Katepalli M, Kohler K, Horohov DW.  Advanced age in horses affects divisional history of T cells and inflammatory cytokine production.  Mechanisms of Ageing and Development. 2008 Nov; 129 (11):  656-64. [Epub Sept 2008].

Katepalli M, Adams AA, Lear TL, Horohov DW.  The effect of age and telomere length on immune function in the horse.  Developmental and comparative immunology. 2008; 32 (12): 1409-15.[Epub 2008 July 9].

Vick MM, Adams AA, Murphy BA, Sessions DR, Horohov DW, Cook RF, Shelton BJ, Fitzgerald, BP.  Relationships among inflammatory cytokines, obesity, and insulin sensitivity in the horse. Journal of Animal Science. 2007 May; 85 (5): 1144-55.

Breathnach CC, Sturgill-Wright T, Stiltner JL, Adams AA, Lunn DP, Horohov DW.  Foals are interferon gamma-deficient at birth.  Veterinary Immunology and Immunopathology.  2006 August 15; 112 (3-4): 199-209.

Yanqiu Li, PhD

Gluck Equine Research Center
Department of Veterinary Science
University of Kentucky
Lexington, KY 40546-0099

yanqiu.li@uky.edu
Tel: 859-257-4757 ext. 81169
Fax: 859-257-8542

Yanqiu Li obtained her Bachelors of Science with a Major in Biology in 1992 from Hubei University, China. During her undergraduate career, she worked as technician in Fishery Science Institute of Hubei Province, China. Subsequently, She started her virology research in State key laboratory of Virology, Department of Microbiology, College of Life Sciences, Wuhan University, China. She received her PhD degree in 2007. Currently, she is a postdoctoral scholar in Dr. Udeni Balasuriya's laboratory. Her current research is focused on Equine Herpesvirus.

Publications:

Yanqiu Li, Jiamin Zhang, Yang Li, Li Tan, Wuguo Chen, haishan Luo, Yuanyang Hu. Phylogenetic analysis of Heliothis armigera cytoplasmic polyhedrosis virus type 14 and a series of dwarf segments found in the genome. J Gen Virol  2007 88: 991-997.

Yang Li, Li Tan, Yanqiu Li, Wuguo Chen, Jiamin Zhang and Yuanyang Hu. Identification and genome characterization Heliothis armigera cypovirus types 5 and Heliothis assulta cypovirus type 14. J Gen Virol 2006 87: 387-394.

Wuguo Chen, Jiamin Zhang，Bo Yang, Yanqiu Li, Chuanfeng Liu, Yuanyang Hu. Identification of transmembrane domain of a membrane associated protein NS5 of Dendrolimus punctatus cytoplasmic polyhedrosis virus. Journal of Biochemistry and Molecular Biology . 2006, 39 (4), 412-417.

LI Dou-lin, LI Yan-qiu, ZHANG Jia-min, et al Expression and Localization of the Dendrolimus punctatus Cypovirus Polyhedrin gene. Virologica Sinica 2006, 21(1) 52-56.

Yi,M.S., Li,Y.Q., Liu,J.D., Zhou,L., Yu,Q.X., Gui,J.F., Molecular cytogenetic detection of paternal chromosome fragments in allogynogenetic gibel carp, Carassius auratus gibelio Bloch. Chromosome Research, 11（7）(2003)：665-671.

Sridhar Velineni, PhD

Gluck Equine Research Center
Department of Veterinary Science
University of Kentucky
Lexington, KY 40546-0099

sridharvelineni@uky.edu
Tel: 859-257-4757 ext. 81155
Fax: 859-257-8542

Sridhar Velineni finished his B.Sc (Agriculture) in 2000 from Acharya N. G. Ranga Agricultural University, Hyderabad, India.  He obtained his M.Sc (Agriculture) with a major in Agricultural Microbiology in 2002 from Gandhi Krishi Vignana Kendra, University of Agricultural Sciences, Bangalore, Karnataka, India. During his M.Sc (Agriculture), he worked on “Development of liquid inoculant using osmoprotectants for phosphate solubilizing bacterium Bacillus megaterium”. Subsequently, he joined in University of Hyderabad and conducted his doctoral research in Prof. Manjula Sritharan’s laboratory in “Studies on the hemin-binding protein HbpA and the iron-regulated virulence factor sphingomyelinase inpathogenic leptospires”.  Currently, he is a post-doctoral fellow in Dr. John. F. Timoney’s laboratory.

Research publications:

Velineni S, Manjulata Devi S, Ahmed, N & Sritharan M. 2008. Diagnostic potential of an iron – regulated hemin binding protein HbpA that is widely conserved in Leptospira interrogans. Infection, Genetics and Evolution. 8: 772 – 776.

Asuthkar S, Velineni S, Stadlmann J, Altmann F & Sritharan M. 2007. Expression and characterization of an iron-regulated hemin-binding protein, HbpA from Leptospira interrogans serovar Lai. Infection and Immunity. 75 (9): 4582 – 4591.

Velineni S, Asuthkar S, Lakshmi V, Umabala P. & Sritharan M. 2006. Serological evaluation of leptospirosis in Hyderabad, Andhra Pradesh – a retrospective hospital based study. Indian Journal of Medical Microbiology. 25 (1): 24 – 27.

Velineni S, Asuthkar S. & Sritharan M . 2006. Iron limitation and expression of immunoreactive outer membrane proteins (OMPs) in Leptospira interrogans serovar Icterohaemorrhagiae strain Lai. Indian Journal of Medical Microbiology. 24 (4): 339 – 342.

Sritharan M, Asuthkar S. & Sridhar V. 2006. Understanding iron acquisition by pathogenic leptospires – a review. Indian Journal of Medical Microbiology. 24 (4): 311 – 316.

Sridhar V, Brahmaprakash GP. & Hegde SV. 2004, Development of a liquid inoculant for phosphate solubilizing bacterium (Bacillus megaterium). Karnataka Journal of Agricultural Sciences. 17(2): 251-257.

Velineni S, Rama Devi S, Asuthkar S. & Sritharan M. 2008. Mechanistic insights into the action of a leptospiral hemolysin (Under Communication to PLoS One).

Conferences & Workshops attended

“CME cum workshop on Leptospirosis, Clinical and diagnostic aspects” held at Dept. of Microbiology, NIMS, Hyderabad on 7th November, 2004.

“Symposium on Recent advances in diagnosis and clinical management of Leptospirosis”, held at Osmania Medical College, Hyderabad on 1st October 2005.

“Symposium on current trends in computational biology” organized by C-DAC, Pune on 24th & 25th November 2005.

“International Conference on Leptospirosis: a diagnostic enigma & 6th scientific meeting of the Indian Leptospirosis Society” organized by Dept. of Animal Sciences, University of Hyderabad between June 20th – 22nd, 2006.

“93rd Indian Science Congress” held at Acharya. N. G. Ranga. Agricultural University, Rajendra Nagar, Hyderabad, India.

“Twin City Meet on recent trends and advances of zoonosis” held at Osmania Medical College, Hyderabad on 5th July 2008 on the eve of World zoonosis day (6th July).

“MICROCON”-2008 held at Armed Forces Medical College (AFMC), Pune from October 22 – 25, 2008.

“Bio-Asia 2009” held in Hitex, Hyderabad between February 2nd & 3rd, 2009.

Jianqiang Zhang, MD, MS, PhD

Gluck Equine Research Center
Department of Veterinary Science
University of Kentucky
Lexington, KY 40546-0099

jzhan8@uky.edu
Tel: 859-257-4757 ext. 81125
Fax: 859-257-8542

Jianqiang Zhang finished his Medical Degree in 1996 at Beijing Medical University, Beijing, China. In 1999 he earned his M.S. degree at the Institute of Virology, Chinese Academy of Preventive Medicine, Beijing, China. Subsequently he conducted his Ph.D. research under the mentorship of Dr. Peter J. Timoney at the Gluck Equine Research Center, University of Kentucky, studying the molecular biology of equine arteritis virus and establishing an in vitro model of persistent equine arteritis virus infection, and received his degree in 2005. Currently he is a post-doctoral scholar in Drs. Udeni Balasuriya and Peter Timoney’s laboratory. His current research is focused on genetic determination of virulence and abortigenic potential of equine arteritis virus, and development of new generation marker vaccines for equine viral arteritis

Publications:

Zhang J., Timoney P.J., MacLachlan N.J., Balasuriya U.B.R. (2008). Identification of an Additional Neutralization Determinant of Equine Arteritis Virus. Virus Research (in press).

Zhang J., Timoney P.J., MacLachlan N.J., McCollum W.H., Balasuriya U.B.R. (2008).  Persistent Equine Arteritis Virus Infection in HeLa Cells. Journal of Virology 82 (17), 8456-8464.

Zhang J., Go Y.Y., MacLachlan N.J., Meade B.J., Timoney P.J., Balasuriya U.B.R. (2008). Amino Acid Substitutions in the Structural or Non-Structural Proteins of a Vaccine Strain of Equine Arteritis Virus are Associated with its Attenuation. Virology 378 (2), 355-362.

Lu Z., Branscum A., Shuck K.M., Zhang J., Dubovi E., Timoney P.J., Balasuriya U.B.R. (2008). Comparison of Two Real-time RT-PCR Assays for the Detection of Equine Arteritis Virus Nucleic Acid in Equine Semen and Tissue Culture Fluid. Journal of Veterinary Diagnostic Investigation 20 (2), 147-155.

Go Y.Y., Wong S.J., Branscum A., Demarest V.L., Shuck K.M., Vickers M.L., Zhang J., McCollum W.H., Timoney P.J., Balasuriya U.B.R. (2008). Development of a Fluorescent Microsphere Immunoassay for Detection of Antibodies Specific to Equine Arteritis Virus and Comparison with the Virus Neutralization Test. Clinical and Vaccine Immunology 15 (1), 76-87.

Zhang J., Guy J.S., Snijder E.J., Denniston D.A., Timoney P.J., Balasuriya U.B.R. (2007). Genomic Characterization of Equine Coronavirus. Virology 369 (1), 92-104.

Zhang J., Miszczak F., Pronost S., Fortier C., Balasuriya U.B.R., Zientara S., Fortier G., Timoney P.J. (2007). Genetic Variation and Phylogenetic Analysis of 22 French Isolates of Equine Arteritis Virus. Archives of Virology 152 (11), 1977-1994.

Timoney P., Fallon L., Shuck K., McCollum W., Zhang J., Williams N. (2007).  The Outcome of Vaccinating Five Pregnant Mares with a Commercial Equine Viral Arteritis Vaccine. Equine Veterinary Education 19 (11), 606-611.

Balasuriya U.B.R., Snijder E.J., Heidner H.W., Zhang J., Zevenboven-Dobbe J.C., Boone J.D., McCollum W.H., Timoney P.J., MacLachlan N.J. (2007). Development and Characterization of an Infectious cDNA Clone of the Virulent Bucyrus Strain of Equine Arteritis Virus. Journal of General Virology 88 (Pt 3), 918-924.