PRESS RELEASES & NEWS
UK Researchers Play a Role in Just Announced Horse
Genome Sequencing Project
LEXINGTON, Ky. (July 21, 2006) -- The National Human Genome Research Institute
(NHGRI) announced Wednesday that it has added the horse genome to it latest
sequencing targets, a project expected to provide powerful new scientific
strategies and methods for research on equine health.
University of Kentucky researchers from the College of Agriculture’s
Maxwell H. Gluck Equine Research Center were instrumental in demonstrating
the importance of the horse genome sequence. Last summer, Ernie Bailey,
Professor of Veterinary Science, submitted a “white paper” proposal
to NHGRI demonstrating the importance of the horse genome sequence to both
scientific research and the horse industry and encouraged NHGRI to consider
sequencing the horse genome. Co-authors on the proposal included scientists
Teri Lear, Research Associate Professor of Veterinary Science, and Jamie
MacLeod, Professor of Veterinary Science and Knight Chair for Musculoskeletal
Sciences.
The sequencing of the horse genome will occur at the Broad Institute in
Boston, with a final assembly to be available by the end of 2006. Scientists
use the term "genome" to denote the entire complement of DNA sequences
shown by an individual.
“While the main scientific objective of NHGRI is enabling a direct
comparison of the horse and human genomes, this information will simultaneously
revolutionize horse research,” said Bailey. “Knowing the full
DNA sequence is a fundamental step necessary to open the ‘black box’ of
equine genetics and will provide horse enthusiasts, horse professionals,
equine veterinarians and equine scientists access to critical new information
and genetic tools.”
According to MacLeod, the project will define the position and exact DNA
sequence for every horse gene. Through further research, it will be possible
to figure out if important genetic determinants exist for many of the critical
health problems that afflict horses and the functional role that contributing
genes have in different disease processes. Likewise, genes that regulate
desirable traits can be identified and studied.
“The Horse Genome Project will have a profound impact on horse research
worldwide,” said MacLeod.
According to Bailey, the decision by NHGRI to sequence the entire equine
genome culminates more than 10 years of collaborative international studies
and workshops coordinated by scientists at the Gluck Equine Research Center.
“Beginning in October 1995 with the first workshop meeting held here
in Lexington, scientists from the United States, Europe, Asia, Australia,
New Zealand and Africa have worked together to develop increasingly detailed
versions of equine gene maps and related genetic tools for horse research.
The efforts have facilitated identification of the causes for several inherited
genetic disorders and desirable traits of horses,” he said.
“We applaud the leadership of the Gluck Equine Research Center scientists
in encouraging the sequencing of the horse genome and expect that their
efforts will continue to be important as gene functions are identified.
The horse industry will certainly benefit as we begin to understand more
about the health and well-being of the horse,” said UK College of
Agriculture Dean Scott Smith.
The availability of the full horse sequence is expected to accelerate studies
already underway and concurrently open important new opportunities for the
Equine Genomics Research Group at the Gluck Equine Research Center. For
instance, with information gained from the sequencing project, Bailey plans
to investigate the genetics of the immune response and developmental diseases
of young horses, MacLeod plans to use the sequence to study changes in gene
expression that are important in the development of osteoarthritis and other
joint diseases and Lear plans to investigate genetic mutations that cause
congenital musculoskeletal diseases and mare infertility.
Major funding for the workshops and collaborative scientific activities
has been provided by the Morris Animal Foundation, the Dorothy Russell Havemeyer
Foundation and the United States Department of Agriculture.
Now that the horse genome sequence will be completed, the next step is
using it effectively to benefit the health and welfare of horses, said Bailey.
Toward this goal, the scientists working on the horse genome submitted a
comprehensive grant application to the Morris Animal Foundation horse consortium
proposal program. The Equine Medical Genetics pre-proposal submitted by
this group was selected as the top priority by the foundation, which will
now work to raise $2.5 million dollars to support the activity.
For more about the NHGRI sequencing announcement, please visit www.genome.gov/19517271.
For more about the Gluck Equine Research Center Genomics Research Group,
please visit www.ca.uky.edu/gluck/ResearchImmunogenetics.asp.
Writers:
Ernie Bailey, 859-257-4757, equigene@uky.edu
Teri Lear, 859-257-4757, equigene@uky.edu
Jamie MacLeod, 859-257-4757, equigene@uky.edu
Holly Wiemers, 859-257-4883, holly.wiemers@uky.edu
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