Gluck Center > Directory > Gluck Faculty > Balasuriya, UBR > Research Projects
RESEARCH PROJECTSMechanisms of EAV Pathogenesis and Persistent Infection of Stallions |
Udeni B.R. Balasuriya, BVSc, MS, PhD
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The clinical manifestations of EVA reflect endothelial injury and increased vascular permeability, however the relative roles and importance of direct virus-mediated endothelial cell injury and virus-induced macrophage-derived vasoactive and inflammatory cytokines in the pathogenesis of EAV-induced vascular injury are not yet clearly defined. Our on going studies are focused on development of in vitro assay systems to study the mechanisms of EAV pathogenesis using cultured equine endothelial cells, lung derived macrophages and peripheral blood derived macrophages. Studies are also focused on identification of specific cell type(s) infected by EAV in the male reproductive tract of the carrier stallion using contemporary laboratory techniques. |
Maxwell H.Gluck Equine Research Center
Department of Veterinary Science, University of Kentucky
Lexington, Kentucky 40546-0099
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