1982-85; Postdoctoral Fellow under D.P. Nayak, Department
of Microbiology and Immunology, UCLA School of Medicine
1985-90; Research Associate under R.G. Webster and Assistant
Member, Department of Virology and Molecular Biology, St.
Jude Children's Research Hospital, Memphis, Tennessee
1990-96; Assistant Professor, Department of Veterinary Science,
University of Kentucky
1996-present; Associate Professor, Department of Veterinary
Science, University of Kentucky
Head of Office International des Epizooties (OIE) Reference
Laboratory for Equine Influenza, 1993-present. This is one
of three such laboratories in the world, and the only one
in the western hemisphere.
Co-inventor of a new equine influenza vaccine (Flu-Avert™
I.N., Heska Corporation) now at market in the USA.
Author or co-author of over 50 journal articles and book
chapters, including the chapter, Equine Influenza, in the
Textbook of Influenza (A. Hay and R. Webster, eds, Blackwell
Scientific Press, 1998), as well as the book, Virology—A
Laboratory Manual (Academic Press, 1992).
Invited speaker at over 40 national and international scientific
or veterinary meetings. Participant at the 2nd and 3rd WHO/OIE
Consultations on Equine Influenza, 1992 and 1995, and co-organizer
of the 4th in 1999. Session chair at the 8th International
Conference on Equine Infectious Diseases (Dubai 1998). Workshop
Chair and member of the Local Committee for the 2002 annual
meeting of the American Society for Virology.
Director of Graduate Studies, Department of Veterinary Science,
1999-2005. Lecturer or faculty participant in several graduate/undergraduate
virology courses, and undergraduate advisor in Agricultural
Biotechnology BS major program. Major Professor of 3 PhD
and 4 MS past recipients and currently of 1 PhD and 1 MS
graduate students.
Co-chair since 2002 of the University of Kentucky’s Institutional
Biosafety Committee.
Lai, A.C.K., Chambers, T.M., Holland, R.E. Jr., Morley,
P.S., Haines, D.M., Townsend, H.G., and Barrandeguy, M.:
Diverged evolution of recent equine-2 influenza (H3N8) viruses
in the Western Hemisphere. Arch. Virol. 146,1063-74, 2001.
Lin, C., Zimmer, S.G., Lu, Z., Holland, R.E. Jr., Dong,
Q., and Chambers, T.M.: The involvement of a stress-activated
pathway in equine influenza virus mediated apoptosis. Virology
287, 202-213, 2001. (The cover illustration for the issue
was from our paper.)
Lin, C., Holland, R.E. Jr., Williams, N.M., and Chambers,
T.M.: Cultures of equine respiratory epithelial cells and
organ explants as tools for the study of equine influenza
virus infection. Arch. Virol. 146, 2239-2247, 2001.
Chambers, T.M., Holland, R.E., Tudor, L.R., Townsend, H.G.,
Cook, A., Bogdan, J., Lunn, D.P., Hussey, S., Whitaker-Dowling,
P., Youngner, J.S., Sebring, R.W., Penner, S.J., and Stiegler,
G.L.: A new modified-live equine influenza virus vaccine:
Phenotypic stability, restricted spread, and efficacy against
heterologous virus challenge. Equine Vet. J. 33, 630-636,
2001.
Townsend, H.G.G., Penner, S.J., Watts, T.C., Cook, A., Bogdan,
J., Haines, D.M., Griffin, S., Chambers, T., Holland, R.E.,
Whitaker-Dowling, P., Youngner, J.S., Sebring, R.W.: Efficacy
of a modified-live, temperature sensitive, intra-nasal vaccine
against equine influenza: Challenge trials. Equine Vet. J.
33, 637-643, 2001.
Chambers, T.M., Lai, A.C.K., Powell, D.G., and Shortridge,
K.F.: Equine influenza in China, including Hong Kong, 1989-1994.
A review. Emergence and Control of Zoonotic Ortho- and Paramyxovirus
Diseases, John Libbey Eurotext, Montrougue (France), pp.
55-64, 2001.
Lin, C.B., Holland, R.E. Jr., Donofrio, J.C., Tudor, L.R.,
and Chambers, T.M.: Caspase activation in equine influenza
induced apoptotic cell death. Vet. Microbiol. 84, 357-365,
2002.
Lai, A.C.K., Rogers, K.M., Glaser, A., Tudor, L., and Chambers,
T.M. Alternate circulation of recent equine-2 influenza viruses
(H3N8) from two distinct lineages in the United States. Virus
Research 100, 159-164, 2004.
Quinlivan, M., Zamarin, D., Garcia-Sastre, A., Cullinane,
A., Chambers, T., and Palese, P.: Attenuation of equine influenza
viruses through truncations of the NS1 protein. J. Virol.
79, 8431-8439, 2005.
