1998 – Present: Research Assistant Professor
Department of Veterinary Science, 108, Gluck Equine Research
Center, University of Kentucky, Lexington, Kentucky 40546
1991 - 1998: Research Specialist
Department of Veterinary Science, 108, Gluck Equine Research
Center, University of Kentucky, Lexington, Kentucky 40546
1989 - 1991: NIH Postdoctoral Researcher
Laboratories of Molecular and Development Biology. Ohio Agricultural
Research and Development Center. The Ohio State University,
Department of Dairy Science 1680, Madison Avenue, Wooster,
Ohio 44691.
1983 - 1988: Virologist/Project Leader
Equine Virology Unit, Animal Health Trust, Lanwades Park,
Kennett,
Newmarket, Suffolk, Great Britain.
1979 - 1983: Postdoctoral Research Fellow: Tumour Virus
Research Group.
University of Warwick, Department of Biological Sciences,
Coventry, CV4 7AL Great Britain.
Detection of influenza nucleoprotein antigen in nasal secretions
from horses infected with equine influenza (H3N8) viruses.
R. F. Cook, R. Sinclair and J. A. Mumford. (1988). J. Virol.
Methods 20, 1 - 12.
The characterization of neutralizing and non-neutralizing
monoclonal antibodies against equine herpes virus type 1.
R. Sinclair, R. F. Cook and J. A. Mumford (1989). J. of General
Virology 70, 455 - 459.
Protection against lethal equine herpesvirus type 1 (subtype
1) infection in hamsters by immune stimulating complexes
containing the major viral glycoproteins. R. F. Cook, T.
O'Neill, R. Sinclair, B. Sundqvist and J. A. Mumford. (1990).
Vaccine 8, 491 - 496.
Retrotransposon gene engineering. R. F. Cook, S. J. Cook
and C. P. Hodgson. (1991). Nature Biotechnology 9, 748 -
751.
Liver-specific expression of a phosphenopyruvate carboxykinase-neo
gene in genetically modified chickens. (1993). R. F. Cook,
S. J. Cook, S. Savon, M. McGrane, M. Hartitz, R. W. Hanson
and C. P. Hodgson. Poultry Science 72 : 554 - 567.
Enhanced sensitivity to neutralizing antibodies in a variant
of Equine Infectious Anemia Virus (EIAV) is linked to amino
acid substitutions in the surface unit (SU) envelope glycoprotein.
(1995). R. F. Cook, S. L. Berger, K. E. Rushlow, J. J. McManus,
S. J. Cook, S. Harrold, M. L. Raabe, R. C. Montelaro and
C. J. Issel. J. Virol. 69 : 1493 - 1499.
Replication in vitro and in vivo of an equine infectious
anemia virus (EIAV) mutant deficient in deoxyuridine triphosphate
(dUTPase) activity. (1995). D. L. Lichtenstein, K. E. Rushlow,
R. F. Cook, M. L. Raabe, C. J. Swardson, G. J. Kociba, C.
J. Issel, and R. C. Montelaro. J. Virol. 69 : 2881 - 2888.
Development and characterization of an in vivo pathogenic
molecular clone of equine infectious anemia virus. (1998).
R. F. Cook, C. Leroux, S. J. Cook, S. L. Berger, D. L. Lichtenstein,
N. N. Ghabrial, R. C. Montelaro and C. J. Issel. J. Virol.
72 (2) : 1383-1393.
Immunization with a recombinant envelope protein (rgp90)
of EIAV produces a spectrum of vaccine efficacy ranging from
lack of clinical disease to severe enhancement. (1998) M.
Raabe, C. J. Issel, S. J. Cook, R. F. Cook, B. Woodson and
R. C. Montelaro. Virology 245 : 151-162.
Effects of long terminal repeat sequence variation on equine
infectious anemia virus replication in vitro and in vivo.
(1999). D. L. Lichtenstein, J. K. Craigo, C. Leroux, K. E.
Rushlow, R. F. Cook, S. J. Cook, C. J. Issel and R. C. Montelaro.
Virology 263 : 408-417
Tissue sites of persistent and active replication of equine
infectious anemia virus during acute and asymptomatic infection
in experimentally infected equids.(2000) S. M. Harrold, S.
J Cook, R. F. Cook, K. E. Rushlow, C. J. Issel and R. C.
Montelaro. J. Virol 74 (7) : 3112-3121
Differential responses of Equus caballus and Equus asinus
to infection with two pathogenic strains of equine infectious
anemia virus. S.J. Cook, R.F. Cook, R.C. Montelaro and C.J.
Issel (2001). Veterinary Microbiology, 79, (2):93-109
Multiple RNA splicing and the presence of cryptic RNA splice
donor and acceptor sites may contribute to low expression
levels and poor immunogenicity of potential DNA vaccines
containing the env gene of equine infectious anemia virus
(EIAV). W. Zhou, R. F. Cook, S. J. Cook, S. A. Hammond, K.
Rushlow, N. N. Ghabrial, S. L. Berger, R. C. Montelaro, and
C. J. Issel, (2002). Veterinary Microbiology, 88 : 127-151.
Development of a multiplex real-time reverse transcriptase-polymerase
chain reaction for equine infectious anemia virus (EIAV).
R. F. Cook, S. J. Cook, F. Li, R. C. Montelaro and C. J.
Issel, (2002). Journal of Virological Methods, 105 : 171-179.
Enhancement of equine infectious anemia virus (EIAV) virulence
by identification and removal of sub-optimal nucleotides.
(2003). R. F. Cook, S. J. Cook, S. l. Berger, C. Leroux,
N. N. Ghabrial, M. Gantz, P. S. Bolin, M. R. Mousel, R. C.
Montelaro and C. J. Issel. Virology, 313 : 588-603.
Genetic immunization with codon-optimized equine infectious
anemia virus (EIAV) surface unit (SU) envelope sequences
stimulates immune responses in ponies. (2005). R. F Cook,
S. J. Cook, P. S. Bolin, L. J. Howe, R. C. Montelaro and
C. J. Issel. Veterinary Microbiology, 108: 23-37.
Evidence of an oscillating peripheral clock in an equine
fibroblast cell line and adipose tissue, but not in peripheral
blood. (2006) B. A. Murphy, M. M. Vick,
D. R. Session, R. F. Cook, B. P. Fitzgerald. Journal of
Comparative Physiology A. 192: 743-751.
Acute inflammation transiently synchronizes clock gene expression
in equine peripheral blood. (2007). B. A. Murphy, M. M. Vick,
D. R. Sessions, R. F. Cook and B. P. Fizgerald.
Brain Behavior Immunity. 21: 467-476.
Relationship between inflammatory cytokines, obesity
and insulin sensitivity in the horse. (2007). M.M. Vick,
A.A. Adams, B.A. Murphy, D.R. Sessions, D.W. Horohov, R.F.
Cook, B.J. Shelton and B.P. Fitzgerald. Journal
of Animal Science, 85:1144-1155.
Real-time quantitative RT-PCR and PCR assays for
a novel European field isolate of equine infectious anaemia
virus based on sequence determination of the gag gene. (2007).
M. Quinlivan, R.F. Cook, and A. Cullinane. Veterinary Record
160:611-618.
Systemic inflammation influences insulin resistance in the horse and increases inflammatory cytokine expression in equine adipose tissue. (2008). M.M. Vick, B.A. Murphy, D.R. Sessions, S.E. Reedy, E.L. Kennedy, D.W. Horohov, R.F. Cook, and B.P. Fitzgerald. Amer. J.of Vet. Res. 69:130-139.
Equine neutrophils respond to PGE2 by activating expression of core circadian clock genes. (2008). B.R. Murphy, C. Merant, M.M. Vick, R.F. Cook, S.A. Brooks, D.W. Horohov and B.P. Fitzgerald. The Open Veterinary Science Journal. 2:96-103.
Full-length and internally deleted forms of interleukin-7 are present in horse (Equus caballus) lymph node tissue. (2008). R.F. Cook, S.J. Cook, D.L. Even, C. Schaffer and C.J. Issel. Veterinary Immunology and Immunopathology. 125:126-134.
