Education
1985; Ph.D., Cornell University, Ithaca, NY
1980; BS, magna cum laude, Cook College, Rutgers University,
New Brunswick, NJ
Employment
2010 to present - Assistant Clinical Professor, University of Kentucky, Director- Animal Genetic Testing and Research Lab.
2005-2010 - Assistant Research Professor, University of Kentucky, Director-Animal Genetic Testing and Research Lab.
1986-2005 - Assistant Research Professor, University of Kentucky, Supervisor-Red Cell Typing and Genetic Research Sections, Equine Parentage Laboratory.
1981-1983 - Graduate Research Assistant, Cornell University.
Professional Society Membership
International Society for Animal Genetics
Publications
Dietert, RR, MA Qureshi, KA Trembicki. Developmental
expression of chicken fetal antigen on peritoneal macrophage:
Implications for hematopoietic differentiation. Proc.
Soc. Exp. Biol. Med. 172:84, 1983.
Qureshi, MA, KA Trembicki, JV Jackson, PE Borenstein,
RR Dietert. Quail fetal antigen (QFA): Identification and
comparison with chicken fetal antigen. Develop. Comp. Immunol.
7:325, 1983.
Trembicki, KA, MA Qureshi, RR Dietert. Avian peritoneal
exudate cells: A comparison of stimulation protocols. Develop.
Comp. Immunol.8:395, 1984.
Trembicki, KA, MA Qureshi, RR Dietert. Differentiation
properties of avian tumor cell lines: Analysis using chicken
fetal antigen and other markers. Cancer Research 44:2616,
1984.
Trembicki, KA, RR Dietert. Chicken developmental antigens:
Analysis of erythroid populations with monoclonal antibodies.
J Exp. Zoo.235:127, 1985.
Trembicki, KA, MA Qureshi, RR Dietert. Monoclonal antibodies
reactive to chicken peritoneal macrophages. Proc. Soc.
Exp. Biol., 183:28, 1986.
Goodloe, RB, RJ Warren, EG Cothran, SP Bratton, KA Trembicki.
Genetic variation and its management applications in Eastern
United States feral horses. J. Wildlife Manage. 55(3):412,
1991.
Cummings, JF, A deLahunta, HO Mohammed, TJ Divers, B Valentine,
BA Summers, BJ Cooper, DF Holmes, KA Trembicki. Equine
Motor Neuron Disease: A new neurologic disorder. Equine
Practice. 13(9):15, 1991.
Lear , TL, KT Graves, RB Ennis. Identification of equine
chromosomes in horse-mouse somatic cell hybrids. Cytogen.
and Cell Genetics. 61:58, 1992.
Cummings, JF, A deLahunta, BA Summers, HO Mohammed, TJ
Divers, BA Valentine, K Trembicki-Graves. Eosinophilic
cytoplasmic inclusions in sporadic equine motor neuron
disease: an electron microscopic study. Acta Neuropath.
85:291, 1993.
Mohammed, HO, JF Cummings, TJ Divers, B Valentine, A deLahunta,
B Summers, BRH Farrow, KA Trembicki-Graves. Risk factors
associated with Equine Motor Neuron Disease: A possible
model forhuman MND. Neurology 43:966, 1993.
Maury, WJ,S Carpenter, KT Graves, B Cheseboro. Cellular
and viral specificity of Equine Infectious Anemia Virus
Tat transactivation. Virology 200, 632-642, 1994.
Bailey, E.G., KT Graves, EG Cothran, R. Reed, TL Lear,
RB Ennis. Synteny mapping horse microsatellite markers
using heterohybridoma panel. Animal Genetics 26: 177-180,
1995.
Mellersh, CS, KT Graves, B McLaughlin, RB Ennis, L Pettitt, M Vaudin, KC Barnett. Mutation In HSF4 Associated With Early But Not Late-Onset Hereditary Cataract In The Boston Terrier. Journal of Heredity 98(5):531-533, 2007.
Graves, KT, PJ Henney and RB Ennis. Partial Deletion of the LAMA3 gene is responsible for hereditary junctional epidermolysis bullosa in the American Saddlebred Horse. Animal Genetics 40(1):35-41, 2009.
Sequence Submissions
Canis familiaris galactokinase gene (GALK1). Complete
codons. GenBank Accession AY267338.KT Graves and RB Ennis.
2003.
Equus caballus laminin alpha3 (LAMA3) gene, intron 25
gi|190684638|gb|EU780072.1|[190684638] KT Graves and PJ Henney.2008
Equus caballus laminin alpha3 chain (LAMA3) gene, exons 23 through 28 and partial cdsgi|188535622|gb|EU704008.1|[188535622] KT Graves and PJ Henney. 2008.
Equus caballus chromosome 8 laminin alpha3 chain (LAMA3) gene, breakpoint region between intron 23 and intron 28 in JEB-affected Saddlebreds. LOCUS EU812567 5027 bp DNA linear MAM 19-JUN-2008. KT Graves and PJ Henney.
TPA_exp: Equus caballus laminin alpha3 chain (LAMA3) gene, exons 23 through 28 and partial cds. LOCUS BK006617 13459 bp DNA linear MAM 22-JAN-2009. KT Graves and PJ Henney.
Book Chapters
Dietert, RR, MA Qureshi, W Gause, KA Trembicki, J Marsh.
Detection of macrophage populations in the thyroids of
Obese Strain chickens using monoclonal antibodies. Avian
Immunology; ed. WT Weber and DL Ewert. pp. 109-123: Alan
R. Liss, Inc., NY, 1987.
Bailey, E, EG Cothran, KA Trembicki. Parentage Testing
in Horses. Equine Reproduction; ed. JL Voss and AO McKinnon.
pp. 626-630.Lea & Febiger, Malvern, Pa. 1993.
Graves, KT. Genetic Testing in Dogs. The Boston Terrier,
by Michael and Beverly Staley. Howell Book Service, New
York, NY 1995.
Abstracts
Dietert, RR, KA Trembicki, MA Qureshi. Chicken fetal
antigen as a differentiation marker on avian tumor cell
lines. Oncodev. Bio. Med.AB2:A91, 1982.
Trembicki, KA, MA Qureshi, RR Dietert. Developmental restriction
of chicken fetal antigen on activated peritoneal macrophage.
Poult. Sci.61:1557, 1982.
Qureshi, MA, KA Trembicki, RR Dietert. Chicken fetal antigen
on normal and tumorigenic hematopoietic cells. Fed. Proc.
42(3):399, 1983.
Trembicki, KA, MA Qureshi, RR Dietert. Stimulation of
avian peritoneal exudate cell populations: A comparative
study. Poult. Sci. 62(7):1514, 1984.
Trembicki, KA, RR Dietert. Monoclonal antibody to an avian
developmental antigen. Fed. Proc. 43(6):1772, 1984.
Dietert, RR, KA Trembicki, DP Hartwell, BF Sanders. Monoclonal
antibodies to chicken fetal antigen: Identification of
erythroid subpopulations. Tumor Biol. 1984.
Trembicki, KA, MA Qureshi, RR Dietert. Monoclonal antibodies
to chicken macrophages: Identification of subpopulations.
ISABR20:114, 1986.
Cothran, EG, RB Goodloe, KA Trembicki, R Warren. Genetics
of Barrier Island horses. ISABR 21:11, 1988.
Carroll, CS, EG Cothran, KA Trembicki. A BC phenotype
in the Q blood group system in horses of feral origin.
Animal Genetics 22:10, 1991.
Graves, KT, RB Ennis, TL Lear, N Raney. Isozyme production
and enumeration of horse chromosomes in horse-mouse somatic
cell hybrids. Animal Genetics 23:F17, 1992.
Bailey, E, KT Graves, EG Cothran. Synteny mapping in the
horse. Proceedings of International Conference on Comparative
Gene Mapping in Terrestrial and Aquatic Vertebrates, 47,
1994.
Bailey, E.G., KT Graves, E.G. Cothran, R. Reed, TL Lear,
and RB Ennis. Gene mapping the horse using microsatellite
markers and somatic cell hybrids. Meeting on Genetic Diseases
in the Horse, Sept. 1994 Interlaken Switzerland (Poster
presentation).
Graves, KT, N Raney, R Ennis, l Coogle, R Reid, E Bailey,
L Van de Goor, EG Cothran, G Guerin, L Skow, M Breen, K
Bell. Equine gene mapping: Synteny mapping DNA markers.
International Society for Animal Genetics, C069, 1996,Tours,
France.
Raney, NR, KT Graves, EG Cothran, E Bailey, L Coogle.
Synteny Mapping of the horse using a heterohybridoma panel.
International Conference on the Status of Plant and Animal
Genome Research. P325, San Diego, CA 1998.
Graves, KT, RB Ennis, P. Henney. Y. Long, L.B. Daugherty.
Approaches to identifying a marker for juvenile cataracts
in Boston Terriers. International Society for Animal Genetics,
1998, Auckland, New Zealand.
Terry, R.R., NE Raney, KT Graves, LT Lieto, PJ Venta,
SL Ewart, EG Cothran, EF Bailey, L. Coogle. Synteny mapping
of the horse using universal mammalian sequence tagged
sites of coding genes and a heterohybridoma panel. International
Conference on the Status of Plant and Animal Genome Research.
P219. San Diego, CA 1999.
Graves, KT and RB Ennis. Comparison of GALK1 exon sequences
in four breeds of dogs affected by juvenile cataracts.
E004, pg. 103. International Society for Animal Genetics,
2000, Minneapolis, MN.
Cothran, EG, KT Graves and R.Juras. Linkage disequilibrium
analysis of Degenerative Suspensory Ligament Desmitis in
the Peruvian Paso. 5th International Equine Gene Mapping
Workshop conducted by the Dorothy Russell Havemeyer Foundation
at Kruger National Park, South Africa, August 11-14, 2003.
Cothran, EG, KT Graves, R Juras and D Strong. Linkage
disequilibrium analysis of degenerative suspensory ligament
desmitis in the Peruvian Paso horse. D045, pg 91. International
Society For Animal Genetics, 2004, Tokyo, Japan.
Mellersh, CS, KT Graves, L Pettitt, OP Forman, M Vaudin, KC Barnett. Different Mutations Within A Single Gene Are Associated With Recessive And Dominant Forms Of Hereditary Cataract In Different Breeds Of Dog. Presented by CS Mellersh at Advances in Canine and Feline Genomics Conference III, Davis, CA, 2006.
Graves, KT, RB Ennis, LB Daugherty, SA Brooks. A SNP in the horse KIT gene as a new marker for the tobiano spotting pattern. D218, pg 23. International Society For Animal Genetics, 2006, Porto Seguro, Brazil.
Graves, KT, PJ Henney and RB Ennis. A 6589 bp deletion in the LAMA3 gene is associated with hereditary junctional epidermolysis bullosa (JEB) in the American Saddlebred Horse. 2229 International Society For Animal Genetics, 2008, Amsterdam, The Netherlands.
McGee RB, Lear TL, Graves KT , Bailey EP. XY Sex Reversal in Mares. P628 Plant & Animal Genomes XVIII Conference, San Diego CA, 2010.
Graves, KT and PJ Henney. Evaluation of candidate genes for late onset hereditary juvenile cataract in the Boston Terrier. P5025 International Society for Animal Genetics, 2010 Edinburgh, Scotland.
Other Publications
Graves, KT. Searching for the Juvenile Cataract Gene,
American Kennel Club Gazette, pp. 86-88, May 1994.
Graves, KT. Juvenile Cataracts. The Frenchie Forum, Official
publication of the French Bulldog Club of America. 11:2,
June 2003, pp 56-57.
Graves, KT. Genetic Disease In The Horse. Journal of Equine
Veterinary Science, 26:6 p. 255.
Graves, KT, Producing Color, Kentucky Mountain Saddle Horse News, 12:2, p. 22, 2006.
Graves, KT, DNA Testing In Horses, The Friesian, Oct/Nov 2007 pp 25-27.
Graves, KT, Neonatal Isoerythrolysis. Equine Disease Quarterly 19:1, 2010.
Grant Proposals
Extramural Funding
Principal Investigator. Canine Health Foundation. Genome-Wide
Scan To Identify Candidate Genes For Inherited Cataracts
In Dogs. Amount requested: $130,246. 2005-2007. Not funded.
Principal Investigator: Canine Health Foundation. Exploration
of a single nucleotide polymorphism in the GALK1 gene as
a potential marker for juvenile cataracts in the Boston
Terrier. Amount requested: $5397.00 Funded.
Principal Investigator: Canine Health Foundation. Galactokinase
1: A Candidate Gene For Juvenile Cataracts In Dogs. 2002-2003.
$22,946. $20,946 Funded.
Co-Investigator: The Jockey Club, Development and characterization
of horse-specific Single Nucleotide Polymorphisms (SniPs).
EG Cothran and KT Graves. 1998. Amount requested $30,500.
Funded.
Co-Investigator: Morris Animal Foundation-Synteny Mapping
of Coding Genes in New World Camelids, E.G. Cothran and
K.T. Graves. 1997-99. $57,000 requested. Approved $28,500.
Principal Investigator: University of Kentucky Research
Committee Grant. Linkage Study to Identify a Microsatellite
Marker for Juvenile Cataracts in the Boston Terrier.K.T.
Graves$4300 requested, $3000 funded. 1997-1998.
Co-Investigator: USDA National research Initiative Competitive
Grants Program, Development of a 250 Marker Comparative
Syntenic Map for the Horse. E. Bailey (PI) and KT Graves.
1996-1999. $360,465 requested. Not funded.
Grayson Jockey Club Research Foundation. Gene Map of the
Horse. E. Bailey (PI), KT Graves, EG Cothran, TL Lear,
L Coogle, co-investigators. 1996-1998. $97,332 requested.
Grayson Jockey Club Research Foundation, Gene Map of the
Horse. E. Bailey (PI), Kathryn T. Graves, E.G. Cothran,
Teri Lear, co-investigators. 1994-1996. $87,412. Funded.
Principal Investigator: Morris Animal Foundation. Identification
of a genetic marker for the juvenile cataract gene in dogs
using bulk segregant RAPD analysis 1994-1996, $50,000 (approved,
not funded).
Private Funding
Co-Principal Investigator: Peruvian Paso Research Foundation.
Genetics of DSLD (Degenerative Suspensory Ligament Desmitis).
E. Gus Cothran and Kathryn T. Graves. 2003-2005. $200,000.
Co-Investigator: Belgian Horse Society ($30,000) and American
Saddlebred Horse Association ($32,000). Investigation of
Laminin 5 as a Candidate Gene for Epitheligenesis Imperfecta.
E. Gus Cothran and Kathryn T. Graves. 2002-2006. $62,000.
Principal Investigator: Galactokinase as a candidate gene
for cataracts in dogs. 1995-2000. Supported with private
donations. $5791.00.
Professional Activities
Ad hoc grant reviewer- Canine Health Foundation, 1997,1998, 2002, 2008, 2009.
Ad Hoc reviewer-Journal of Heredity 2005.
Chair- Dog Map Committee. International Society for Animal Genetics. 2004-2008.
Reviewer-Abstracts for International Society of Animal Genetics Conference XXX, 2006.
Meetings
International Society for Animal Genetics XXXII, Edinburgh, Scotland. Poster presented, Dog Genome Map workshop Co-Chair 2010.
International Society for Animal Genetics XXXI, Amsterdam, The Netherlands. Poster presented, Dog Genome Map workshop Chair 2008.
International Society for Animal Genetics XXX, Porto Seguro, Brazil. Poster presented. Dog Genome Map workshop Chair 2006.
International Society for Animal Genetics XXIX, Tokyo,
Japan. Poster presented. 2004.
International Society for Animal Genetics, XXVII, Minneapolis,
MN. Poster presented. 2000.
International Society for Animal Genetics, XXVI, Auckland,
New Zealand. Poster presented. 1998.
International Society for Animal Genetics, XXV, Tours,
France, 1996. Poster presented.
First International Workshop on Gene Mapping in the Horse,
Lexington, KY. 1995.
Molecular Genetics and Canine Genetic Health Conference,
Florham Park, N.J., 1994.
International Society for Animal Genetics, XXIII, Interlaken,
Switzerland, 1992. Poster presented.
International Society for Animal Genetics, XXII, East
Lansing, MI 1990. Poster presented.
International Society for Animal Genetics, XXI, Torino,
Italy, 1988. Poster presented.
Universityof Pittsburgh Human Genetics Conference, Pymatuning,
PA, 1986.
International Society for Animal Blood Group Research(ISABR)
XX, Helsinki, Finland, 1986. Poster presented.
International Society of Oncodevelopmental Biology and
Medicine, XII Annual meeting, Houston, TX, 1984. Poster
presented.
American Association of Immunologists, FASEB, ST. Louis,
MO, 1984. Poster presented.
Poultry Science Association, College Park, MD, 1983. Paper
presented.
NE-60 Regional Meeting-Genetic Basis of Resistance to
Avian Disease. Ithaca, NY, 1982.
Poultry Science Association, Davis, CA, 1982. Paper presented.
Inter-University Collaboration
Investigation of anti-red cell antibody involvement
in stallion infertility. University of Pennsylvania,
New Bolton Center, Kennett Square, PA. 1991.
Examination of potential genetic markers for Equine Motor
Neuron Disease. John Cummings, PI. New York State College
of Veterinary Medicine, Cornell University, Ithaca NY.
1991-1992.
Permissiveness of horse-mouse somatic cell hybrids for
Tat transactivation by Equine Infectious Anemia Virus.
Wendy Maury, PI. NIH, Rocky Mountain Labs, Hamilton, MT,
1993.
Permissiveness of horse-mouse somatic cell hybrids for
infection and replication of Equine Infectious Anemia Virus.
Susan Payne, PI. Case Western Reserve University, Cleveland,
OH, 1993.
Committee Activity
Graduate Faculty- Associate member, 1988 to present.
Member- Search committee for Warren Wright Sr.-Lucille
Markey Chair in Immunology, 1988 to 1990.
Member-Department of Veterinary Science Animal Resources
Committee, 1988 to 1995.
Member-Department of Veterinary Science Appointments and
Promotions Committee, 1992 to 1999.
Member-Albert and Lorraine Clay Fellowship Award Committee,
1995 to present.
Chair-Department of Veterinary Science Animal Pathology
Building Safety Committee, 1996 to 2009.
BEAC Floor Leader-Department of Veterinary Science 2009 to present.
Member- Department of Veterinary Science Advisory and Strategic Planning Committee 2008 to present.
Member- Department of Veterinary Science Communications Committee 2007 to present.
Student Advising
Graduate
Nancy Raney, MS. Graduate, Major Advisor, 1994-1999.
Teri Lear, Ph.D. candidate, Advisory Committee member,
1993-1997.
Jennifer Leigh Myka, Ph.D.candidate, Advisory Committee
member, 1994.
Diane Strong, MS candidate, Advisory Committee Member,
2004-present.
Undergraduate
Brian York, Biotechnology Program. Project Advisor “Identifying
a DNA marker for cataracts in a family of horses”.
1997-1999.
Nancy Raney, Biotechnology Program. Project and academic
advisor. 1990-1994. Recipient of the 1994 Oswald Research
and Creativity program award in Biological Sciences for
the paper "Use of Horse-Mouse Somatic Cell Hybrids
for Gene Mapping in the Horse"
Pre-veterinary advisor, 1994-2009.
Public Service
Presentation on "Horse Blood Typing at the University
of Kentucky", to the Steward Accreditation class
of the University of Louisville. 1990.
Officiating as judge at the State 4-H Horse Bowl Contest.
University of Kentucky, Lexington, 1990.
1990 ITEC Conference-Presentation on Horse Blood Typing
at the Kentucky Equine Research Foundation booth.
Officiating as judge at the State 4-H Horse Bowl contest,
Louisville, 1992.
Presentation "Juvenile Cataracts-Potential for Genetic
Testing" at the National Specialty Show of the Boston
Terrier Club of America, 1993. Invited Speaker.
Elected Representative of the Boston Terrier Club of America
at the AKC Parent Club Genetic Conference, Florham Park,
NJ, 1995.
Officiated as a judge for the 4-H State Horse Demonstration
Competition. Lexington, KY 1997.
Invited Speaker. Lexington Kennel Club.“Canine Genetics-
Basic Tools for Dog Breeders”. 1997.
Invited Speaker. Lexington Kennel Club. "The Dog
Gene Map: Where is it Going?" 1999.
Officiating as judge at the State 4-H Horse Bowl contest,
Lexington, 2004.
Presentation: Genetic Testing at the University of Kentucky Equine Parentage Lab. Presented to the Akhal-Teke Association of America, Lexington KY 2006.
Presentation: Genetic Testing at the University of Kentucky Equine Parentage Lab. Presented at the Horsemen Helping Horseman Education Event, Harrison County 4-H, Cynthiana KY 2007.
Presentation Genetic Testing at the University of Kentucky Equine Parentage Lab. Presented to the Gotland Pony Society of North America, Lexington KY 2007.
Presentation “The Quest for the EI Mutation: A Success Story” to the American Saddlebred Horse Association Board of Directors, Lexington KY 2007.
Presentation “Genetic Testing In Horses” at the Kentucky Breeders Short Course, Lexington KY 2010.
Presentation “Genetic Testing in Dogs:How to Use It, Not Misuse It” at the United States of America Coton de Tulear Club National Specialty Show, 2010.
Outside Activities
Association Memberships
American Quarter Horse Association-Life Member
American Paint Horse Association
Pinto Horse Association of America
Kentucky Quarter Horse Association
Kentucky Paint Horse Breeders Association- Secretary/Treasurer
Kentucky Paint Horse Club
Pinto Organization of Kentucky
Boston Terrier Club of America
Boston Terrier Club of Greater Cincinnati
Boston Terrier Club of Louisville
Lexington Kennel Club
|
