University of Kentucky College of Agriculture

 

Gluck Center > Directory > Gluck Faculty >Horohov, DW > Curriculum Vitae

CURRICULUM VITAE

David W. Horohov, Ph.D.
David.Horohov@uky.edu
(859) 257-4757 ext 81098

Professor
Department of Veterinary Science
William Robert Mills Chair in Equine Immunology
M.H. Gluck Equine Research Center
College of Agriculture
University of Kentucky

Birthdate

September 2, 1956

Education

Penn State University, University Park, PA; B.S. 1978; Entomology

Purdue University, W. Lafayette, IN; M.S. 1981; Insect Pathology

University of Tennessee, Knoxville, TN; Ph.D. 1985; Immunology

Food and Drug Administration, Bethesda, MD; Post-doc 1988; Cytokine Biology

Research and/or Professional Experience

7/87- 6/88; Staff Fellow. Division of Cytokine Biology, Food and Drug Administration, Bethesda, MD.

6/88 6/91; Assistant Professor of Veterinary Immunology, Department of Veterinary Microbiology, and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70808.

9/90-8/03; Director, School of Veterinary Medicine's Flow Cytometry Facility, Louisiana State University, Baton Rouge, LA 70808.

7/91 6/95; Associate Professor of Veterinary Immunology, Department of Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70808.

7/95 8/03; Professor of Veterinary Immunology, Department of Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70808.

1/98; Visiting Professor, Department of Animal Sciences, Cook College, Rutgers University, New Brunswick, NJ.

7/99-12/99; Visiting Scientist, Sabbatical Leave, Animal Health Trust, Newmarket, UK.

8/03-Present; William Robert Mills Chair and Professor, Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546-0099.

1/04-Present; Adjunct Professor, Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70808.

Recent Publications

Breathnach, C. C., T. Sturgill-Wright, J. L. Stiltner, A. A. Adams, D. P. Lunn, and D. W. Horohov. (2006). Foals are interferon gamma-deficient at birth. Veterinary immunology and immunopathology 112:199-209. PubMed. PDF.

Pena, M. T., J. E. Miller, and D. W. Horohov. (2006). Effect of CD4+ T lymphocyte depletion on resistance of Gulf Coast Native lambs to Haemonchus contortus infection. Veterinary parasitology 138:240-246. PubMed. PDF.

Slater, J. D., D. P. Lunn, D. W. Horohov, D. F. Antczak, L. Babiuk, C. Breathnach, Y. W. Chang, N. Davis-Poynter, N. Edington, S. Ellis, C. Foote, L. Goehring, C. W. Kohn, J. Kydd, T. Matsumura, J. Minke, P. Morley, J. Mumford, T. Neubauer, D. O'Callaghan, K. Osterrieder, S. Reed, K. Smith, H. Townsend, K. van der Meulen, M. Whalley, and W. D. Wilson. (2006). Report of the equine herpesvirus-1 Havermeyer Workshop, San Gimignano, Tuscany, June 2004. Veterinary immunology and immunopathology 111:3-13. PubMed. PDF.

Miller, J. E., and D. W. Horohov. (2006). Immunological aspects of nematode parasite control in sheep. Journal of animal science 84 Suppl:E124-132. PubMed. PDF.

Horohov, D.W., Beadle, R.E., Mouch, S. & Pourciau, S.S. (2005). Temporal regulation of cytokine mRNA expression in equine recurrent airway obstruction. Vet Immunol Immunopathol 108, 237-45. PubMed. PDF.

Kleiber, C., McGorum, B.C., Horohov, D.W., Pirie, R.S., Zurbriggen, A. & Straub, R. (2005) Cytokine profiles of peripheral blood and airway CD4 and CD8 T lymphocytes in horses with recurrent airway obstruction. Vet Immunol Immunopathol 104, 91-97. PubMed. PDF.

Bowles, K., D. Horohov, D. Paulsen, C. Leblanc, M. Littlefield-Chabaud, T. Ahlert, K. Ahlert, S. Pourciau, & Penn, A. (2005). Exposure of adult mice to environmental tobacco smoke fails to enhance the airway response to inhaled ovalbumin. Inhal Toxicol 17(1), 43-51. PubMed. PDF.

Jackson, K. A., Stott, J. L., Horohov, D. W. & Watson, J. L. (2004). IL-4 induced CD23 (Fc(?)RII) up-regulation in equine peripheral blood mononuclear cells and pulmonary alveolar macrophages. Vet Immunol Immunopathol 101:243-50. PubMed. PDF.

Tetens, J., R. M. Moore, G. L. Hosgood, S. C. Eades, M. L. Keowen, and D. W. Horohov. (2004). Effects of infusion of adenosine triphosphate-magnesium chloride on cardiopulmonary and clinicopathologic variables, cytokine activity, and endothelin concentration in horses administered a low dose of endotoxin. American journal of veterinary research 65:225-237. PubMed. *

Hubert, J.D., Seahorn, T.L., Klei, T.R., Hosgood, G., Horohov, D.W., & Moore, R.M.(2004). Clinical signs and hematologic, cytokine, and plasma nitric oxide alterations in response to Strongylus vulgaris infection in helminth-naïve ponies. Can J Vet Res 68 (3) 193-200. PubMed. PDF.

Pena, M. T., Miller, J. E., & Horohov, D. W. (2004). Effect of dexamethasone treatment on the immune response of Gulf Coast Native lambs to Haemonchus contortus infection. Vet Parasitol 119: 223-35. PubMed. PDF.

Horohov, D. W. (2003). Is exercise bad for the immune system? Equine veterinary journal 35:113-116. PubMed. PDF.

Marti, E., D. W. Horohov, D. F. Antzak, S. Lazary, and D. Paul Lunn. (2003). Advances in equine immunology: Havemeyer workshop reports from Santa Fe, New Mexico, and Hortobagy, Hungary. Veterinary immunology and immunopathology 91:233-243. PubMed. PDF.

Fermaglich, D. H., and D. W. Horohov. (2002). The effect of aging on immune responses. The Veterinary clinics of North America 18:621-630, ix. PubMed.

Cunningham, F. M., Vandergrifft, E., Bailey, S. R., Sepulveda, M. F., Goode, N. T., & Horohov, D. W. (2003). Cloning, expression and biological activity of equine interleukin (IL)-5. Vet Immunol Immunopathol 95: 63-72. PubMed. PDF.

Soboll, G., Horohov, D.W., Aldridge, B.M., Olsen, C.W., McGregor, M.W., Drape, R.J., Macklin, M.D., Swain, W.F., & Lunn, D.P. (2003) Regional antibody and cellular immune responses to equine influenza virus infection, and particle mediated DNA vaccination. Vet Immunol Immunopathol 94: 47-62. PubMed. PDF.

Bowles, K.S., Beadle, R.E., Mouch, S., Pourciau, S.S., Littlefield-Chabaud, M.A., Le Blanc, C., Mistric, L., Fermaglich, D. & Horohov, D.W. (2002) A novel model for equine recurrent airway obstruction. Vet Immunol Immunopathol 87, 385-9. PubMed. PDF.

Beadle, R.E., Horohov, D.W. & Gaunt, S.D. (2002) Interleukin-4 and interferon-gamma gene expression in summer pasture-associated obstructive pulmonary disease affected horses. Equine Vet J 34:389-94. PubMed. PDF.

Horohov D.W., Kydd J.H. & Hannant D. (2002) The effect of aging on T cell responses in the horse. Dev Comp Immunol 26, 121-8. PubMed.

LeBlanc, M.M., Giguere, S., Brauer, K, Paccamonti, D. L.,Horohov, D. W.,Lester, G. D., O'Donnell, L. J., Sheerin, B. R., & Pablo, L. (2002) Premature delivery in ascending placentitis is associated with increased expression of placental cytokines and allantoic fluid prostaglandins E-2 and F-2 alpha. Theriogenology 58, 841-4. PDF.

Lunn D.P., Hussey S., Sebing R., Rushlow K.E., Radecki S.V., Whitaker-Dowling P., Youngner J.S., Chambers T.M., Holland R.E., Jr. & Horohov D.W. (2001) Safety, efficacy, and immunogenicity of a modified-live equine influenza virus vaccine in ponies after induction of exercise-induced immunosuppression. J Am Vet Med Assoc 218, 900-6. PubMed. *

Horohov, D. W., S. S. Pourciau, L. Mistric, A. Chapman, and D. H. Ryan. (2001). Increased dietary fat prevents sleep deprivation-induced immune suppression in rats. Comparative medicine 51:230-233. PubMed.

Guirnalda P.D., Malinowski K., Roegner V. & Horohov D.W. (2001) Effects of age and recombinant equine somatotropin (eST) administration on immune function in female horses. J Anim Sci 79, 2651-8. PubMed. PDF.

Folsom R.W., Littlefield-Chabaud M.A., French D.D., Pourciau S.S., Mistric L. & Horohov D.W. (2001) Exercise alters the immune response to equine influenza virus and increases susceptibility to infection. Equine Vet J 33, 664-9. PubMed. PDF.

Edmonds J.D., Horohov D.W., Chapman M.R., Pourciau S.S., Antoku K., Snedden K. & Klei T.R. (2001) Altered immune responses to a heterologous protein in ponies with heavy gastrointestinal parasite burdens. Equine Vet J 33, 658-63. PubMed. PDF.

 

Maxwell H.Gluck Equine Research Center
Department of Veterinary Science, University of Kentucky
Lexington, Kentucky 40546-0099

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