Education
1997; University of Kentucky, Department of Veterinary
Science, Ph.D. (Genetics).
1986; University of Louisville, Department of Biology,
M.S. (Cytogenetics/Zoology).
1975; Indiana University Southeast, Department of Natural
Sciences, B.A. (Zoology/Field Biology).
Academic Positions
2005-present; Research Associate Professor, Molecular
Cytogenetics, Department of Veterinary Science, University
of Kentucky
1998-2005; Research Assistant Professor, Molecular Cytogenetics,
Department of Veterinary Science, University of Kentucky.
Selected Publications
Wade CM, Guilotto E, Sigurdsson S, Zoli M, Gnerre S, Imsland F, Lear TL, et al. (2009). Genome sequence, comparative analysis and population genetics of the domestic horse. Science, 6 Nov, 326:865-869.
Lear TL, Bailey E (2008). Equine clinical cytogenetics: The past and future. Cytogenetic and Genome Research, 120:42-49.
Lear TL, Lundquist J, Zent WW, Fishback WD Jr, Clark A (2008). Three autosomal chromosome translocations associated with repeated early embryonic loss (REEL) in the domestic horse (Equus caballus). Cytogenetic and Genome Research, 120:117-122.
Brooks S, Lear TL, Adelson D, Bailey E (2007). A chromosome inversion near the KIT gene and tobiano spotting pattern in horses. Cytogenetic and Genome Research, 119:225-230.
Ward TL, Valberg SJ, Lear TL, Guerin G, Milenkovic D, Swinburne J, Binns MM, Chowhary BP, Raudsepp T, Skow L, Mickelson JR (2003). Genetic mapping of GBE1 and its association with glycogen storage disease IV in American Quarter horses. Cytogenetics and Genome Research 102:201-206.
Myka JL, Lear TL, Houck ML, Ryder OA, Bailey E (2003). Homologous fission event(s) implicated for chromosomal polymorphisms among 5 species in the genus Equus. Cytogenetic and Genome Research 201:217-221.
Milenkovic D, Oustry-Vaiman A, Lear TL, Billault A, Mariat D, Piumi F, Schibler L, Cribiu E, Guerin G (2002). Cytogenetic localization of 136 genes in the horse: comparative mapping with the human genome. Mammalian Genome 13:524-534.
Lear TL, Layton G (2002). Use of Zoo-FISH to characterize a reciprocal translocation in a Thoroughbred mare: t(1;16)(q16;q21.3). Equine Veterinary Journal 43:207-209.
Lear TL, Brandon R, Piumi F, Terry RR, Guerin G, Thomas S, Bailey E (2001). Mapping of 31 horse genes in BACs by FISH. Chromosome Research 9: 261-262.
Lear TL, Cox JH, Kennedy GA (1999). Autosomal Trisomy in a Thoroughbred Colt: 65,XY,+31. Equine Veterinary Journal 31: 85-88.
Lear TL, Adams MH, Sullivan ND, McDowell KJ, Bailey E (1998). Chromosomal localization of ESR and PR3 in the horse by FISH. Cytogenetics and Cell Genetics 82: 110-111.
Lear TL, Coogle LD, Bailey E, (1998). Assignment of the horse mitochondrial glutamate transaminase 2 (GOT2) and v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT) to horse chromosome 3 by in situ hybridization. Cytogenetics and Cell Genetics 82:112-113.
Lear TL, Bailey E, Ponce de Leon FA, Breen M, Coogle L, Ferguson EM, Chambers TM (1998). Cloning and chromosomal localization of MX1 and ETS2 to chromosome 26 of the horse (Equus caballus). Chromosome Research 6: 333-336.
ISCNH (1997), International system for cytogenetic nomenclature of the domestic horse. Bowling AT, Breen M, Chowdhary BP, Hirota K, Lear TL, Millon LV, Ponce de Leon FA, Raudsepp T, Stranzinger G, (Committee). Chromosome Research 5:433-453.
Book Chapters
Lear TL, Villagomez D. The Mare: Techniques in Reproductive Examination - Cytogenetic abnormalities in mares and foals. In: Equine Reproduction. McKinnon AO, Squires EL, Vaala WE and Varner DD (eds), Lea and Febiger, in press.
Houck ML, Lear TL, Suellen Charter (2009). Animal Cytogenetics. In: The AGT Cytogenetics Laboratory Manual, Third Edition. Barch M, et al eds., in press.
Lear TL (2006). Cytogenetic Evaluation. In: Current Therapy in Equine Reproduction. JC Samper, JF Pycock, AO McKinnon (eds), Elsevier Science, St. Louis. (2006).
Selected Abstracts
McGee RB, Lear TL, Graves KT, Bailey E (2010). XY sex reversal in mares. Plant & Animal Genome XVIII, San Diego, CA.
Lear TL, McGee R, Mains C, Bailey E (2009). Characterization of SRY deletions in female horses with a 64,XY karyotype. Proceedings of the American Society of Human Genetics, Honolulu Hawaii, November.
Lear TL (2009). Assessing chromosome abnormalities in horses with infertility or congenital abnormalities. Proceedings of the Equine Science Society Conference, May, Keystone CO. Journal of Equine Veterinary Science 29: 316-317.
Villagomez DAF, Lear TL, Chenier T, Lee S, Cahill J, King WA (2008). Equine XY and XX sex-reversal syndrome in Sry positive and negative mares. Proceedings of the 18th International Colloquium on Animal Cytogenetics and Gene Mapping, June, Bucharest, Romania. Chromosome Research, 16:1040.
Lear TL, Lundquist J (2008). Chromosomal aberration associated with congenital abnormalities, infertility and repeated early embryonic loss in the domestic horse (Equus caballus). Proceedings of the 40th Biennial American Cytogenetics Conference, April 10-13, Monterey, CA. Cytogenetic and Genome Research, 121:78-107.
Lear TL (2005). Using horse gene mapping tools to study chromosome evolution in Perissodactyls. Plant & Animal Genome Conference XIII, San Diego, CA.
Lear TL, Houck ML, Lundquist JM, Fronczek JA, Ryder OA (2005). Comparative gene mapping of endangered rhinoceros species. Plant & Animal Genome XIII, San Diego, CA.
Lear TL, Houck ML, Ryder OA (2003). Comparative cytogenetics and gene mapping in Rhinoceroses. 13th North American Colloquium on Animal Cytogenetics and Gene Mapping, Louisville, KY.
Lear TL, Houck M, Zhang YW, Debnar LA, Sutherland-Smith MR, Young L, Bernirschke K, Jones KL, Ryder OA (2001). Comparative clinicial cytogenetics of hominoid primates: Pan paniscus equivalent of human trisomy 18 and equivalent of human deletion 4q associated with developmental anomalies in Gorilla gorilla. American Genetic Association Annual Meeting, San Diego.
Lear TL, Cox JH, Kennedy GA (1997). Autosomal trisomy in a thoroughbred colt: 65,XY,+31. 10th North American Colloquium on Gene Mapping and Cytogenetics in Human and Domestic Species, Apalachicola.
Lear TL, Bennett SD, Behling H, Foster WR, Jackson SG (1989). The analysis of metaphase chromosomes from equine amniocytes. Sixth North American Colloquium on Cytogenetics of Domestic Animals, Purdue, p. 5.
Bennett SD, Behling H, Lear T, Jackson S (1989). Equine amniocentesis. Equine Veterinary Journal 8: 86.
Popular Press
Bailey E, Lear TL (2009). Closing in on the cause of swayback. American Saddlebred, The American Saddlebred Horse Association.
Lear TL (April 2009). Early embryonic loss and genetics. Equine Disease Quarterly.
Lear TL (Oct 2008). Contracted foal syndrome. Equine Disease Quarterly.
Lear TL (August 2006). The Horse Genome Project: what does it mean? American Saddlebred, The American Saddlebred Horse Association.
Lear TL (Jan, 2001). “Chromosomal abnormalities in horses”, Equine Disease Quarterly.
Lear TL (April, 2000). “Equine Genome Project”, Equine Disease Quarterly.
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