Gluck Equine Research Center

DEPARTMENT OF VETERINARY SCIENCE

 

Gluck Center > Directory > Gluck Faculty >Lear, T > Research Interests

RESEARCH INTERESTS

Understanding the Evolution of Genome Organization of the Horse
and other Perissodactyls by Comparative Mapping Approaches

Teri Lear, PhD
equigene@uky.edu
(859) 257-4757 ext 81108

Our research is leading to a better understanding of the mechanisms responsible for the rapid chromosome and genome evolution of the equids, how speciation occurs, and potentially how genomic differences enable some exotic equid species to avoid serious infection by certain disease pathogens, while infection in horses in often fatal (Myka et al. 2003a, 2003b). 

Recently, in collaboration with the genetics group at Conservation for Research on Endangered Species (CRES) of the San Diego Zoological Society, we have characterized the chromosomes of endangered rhinoceros species by molecular cytogenetics.  This research has identified a very high degree of genome conservation among all rhinoceros species and that centromere shifts have contributed to chromosome evolution in Perissodactyls. 

We are now studying the genome organization of tapirs.

Three horse genes on the X chromosome of rhinoceros
Photo: Three horse genes on the X chromosome of rhinoceros.

Indian Rhinoceros
Indian Rhinoceros at San Diego Zoo.
Photo courtesy of Dr. Mike Mienaltowski.

 

Members of the Order Perissodactyla
 
Diploid Chromosome #
(# Polymorphism)
Family Equidae
Equus przewalskii
66
E. caballus
64
E. asinus
62
E. africanus
62 (63,64)
E. hemionus onager
56 (55)
E. hemionus kulan
54 (55)
E. kiang
52 (51)
E. grevyi
46
E. burchelli
44 (45)
E. zebra hartmannae
32
Family Rhinocerotidae
Rhinoceros unicornis
82
Dicerorhinus sumatrensis
82 (81)
Ceratotherium simum simum
82
C. simum cottoni
82 (81)
Diceros bicornis michaeli
84 (83)
D. bicornis minor
84 (83)
R. sondaicus
?
Family Tapiridae
Tapirus indicus
52
T. pinchaque
76
T. bairdii
80
T. terrestris
80

 

Maxwell H.Gluck Equine Research Center
Department of Veterinary Science, University of Kentucky
Lexington, Kentucky 40546-0099

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