Gluck Center > Directory > Gluck Faculty > MacLeod, JN
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Laboratory of Equine Musculoskeletal SciencesPhysical exertion and the musculoskeletal stress of athletic events predispose both horses and humans to joint injuries. In fact, pain and lameness associated with joint disease is a primary variable that limits many athletic careers. My laboratory conducts biomedical research on articular cartilage, primarily focused on the cell biology of chondrocytes. We study changes in chondrocyte gene expression that occur during normal maturation, when joints develop arthritis, and associated with efforts to heal joint surface lesions. Additional experiments focus on how the function of cartilage and synovial cells is regulated by cell/matrix interactions and influenced by intra-articular medications. Finally, we are interested in genomics and the identification of genetic determinants that influence both congenital and acquired musculoskeletal diseases. Projects:Articular Cartilage Maturation and Repair Osteoarthritis Pathogenesis and Therapy Cartilage-Restricted Fibronectin Isoform Gene Mapping, SNP Genotyping, Association Studies, and Transcriptional Profiling
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James N. MacLeod, VMD, PhD
Maxwell H.Gluck Equine Research Center
Department of Veterinary Science, University of Kentucky
Lexington, Kentucky 40546-0099
Main Office (859) 257-4757
Fax (859) 257-8542