Research Accomplishment Reports 2010

Reference Standards, Internal Standards and Critical Reagents/Regulatory Analytes for Analytical/Toxicological Approaches to Problems in Equine Medicine

T. Tobin
Department of Veterinary Sciences

 

Non-Technical Summary

Objectives:

1/ To identify, synthesize and make available to equine forensic chemists worldwide certified reference standards for unique urinary drug/metabolite fragments for therapeutic medication regulation.

2/ To synthesize and make available to equine forensic chemists worldwide deuterated or other stable isotope internal reference standards for the above unique urinary drug/metabolite fragment standards to allow accurate forensic quantification.

3/ To identify and synthesize certified reference standards and stable isotope internal standards for glucuronide metabolites of high potency therapeutic medications.

4/ To develop cost-effective methods of synthesizing ergovaline and related ergot alkaloids and haptens of same with the goal of creating highly sensitive and specific ELISA tests for these substances.

5/ To complete ongoing work on establishing the therapeutic efficacy of diclazuril in the therapy and prophylaxis of certain Toxoplasma related syndromes.